Correlation of interferon-gamma production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis.

Full Abstract

The contribution of interferon-gamma (IFN-gamma) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-gamma (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-gamma and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-gamma is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.

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Author information

Author/s: Haque, Rashidul (R); Mondal, Dinesh (D); Shu, Jianfen (J); Roy, Shantanu (S); Kabir, Mamun (M); Davis, Andrea N (AN); Duggal, Priya (P); Petri, William A (WA);

Affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

Grants: AI-43596 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg), published in United States. (Language: eng)

Reference: 2007-Feb; vol 76 (issue 2) : pp 340-4

Dates: Created 2007/02/13; Completed 2007/04/03; Revised 2008/11/21;

PMID: 17297046, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Anthropometry
Bangladesh
Child, Preschool
Cohort Studies
Diarrhea - blood; immunology; parasitology
Entamoeba histolytica - immunology
Entamoebiasis - blood; immunology; parasitology
Enzyme-Linked Immunosorbent Assay
Feces - parasitology
Female

Humans
Interferon-gamma - biosynthesis; blood; immunology
Interleukin-5 - biosynthesis; immunology
Kaplan-Meiers Estimate
Leukocytes, Mononuclear - immunology
Male
Malnutrition - blood; immunology
Poverty Areas
Proportional Hazards Models
Prospective Studies
Urban Population

Associated Chemicals: Interleukin-5 (0) ; Interferon-gamma (82115-62-6)

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