Aggregation of cancer among relatives of never-smoking lung cancer patients.

Full Abstract

The authors evaluated the familial aggregation of lung and other cancers in first-degree relatives of lung cancer patients self-reported to be lifetime never smokers. The data, derived from a large lung cancer case-control study, included 2,465 first-degree relatives of 316 never smoker lung cancer cases and 2,441 first-degree relatives of 318 never smoker controls, frequency matched to the cases on age, gender and ethnicity. The median age of the cases and the controls was 61 years, about 2/3 were women, and about 80% were Caucasian. Overall, there was a 25% excess risk [95% CI (1.05-1.50)] of any type of cancer among the first-degree relatives of cases, and case offspring exhibited a 2-fold excess cancer risk (1.03-4.10) compared with control offspring. There was also a 44% excess risk (1.05-1.97) of young onset cancers (before age 50) among relatives of cases. Smoking case relatives had an increased risk of any cancer [odds ratio (OR) = 1.36 (1.03-1.81)] and a 5.52-fold risk (1.19-25.51) of young onset lung cancer compared with smoking control relatives. Female case relatives had a 58% excess breast cancer risk (1.04-2.43), and case mothers a 2.57-fold breast cancer risk (1.16-4.24). A significant excess of testicular cancer was observed among case male relatives [OR = 12.32 (1.71-88.90)], although based on only 9 cases. The age at lung cancer diagnosis tended to be earlier in case relatives (61.4, SD = 12.9) compared with control relatives (66.2, SD = 11.4; p = 0.07). Our analysis provides further evidence for the importance of genetic factors for lung cancer in never smokers.

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Author information

Author/s: Gorlova, Olga Y (OY); Weng, Shih-Feng (SF); Zhang, Yiqun (Y); Amos, Christopher I (CI); Spitz, Margaret R (MR);

Affiliation: Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA. oygorlov(-atsign-)mdanderson.org

Grants: R01 CA55769 (Agency:NCI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2007-Jul; vol 121 (issue 1) : pp 111-8

Dates: Created 2007/04/30; Completed 2007/06/18; Revised 2007/11/14;

PMID: 17304511, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Distribution
Aged
Family
Female
Humans
Lung Diseases - epidemiology; pathology

Lung Diseases - epidemiology; pathology
Male
Middle Aged
Neoplasms - epidemiology; pathology
Risk Factors
Smoking

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