Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-up.

Full Abstract

BACKGROUND:
Behavioral disinhibition refers to a temperamental tendency to exhibit boldness, approach, and spontaneity in unfamiliar situations. We previously found it to be associated with childhood disruptive behavior and mood disorders, as well as with parental bipolar disorder. In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders.

METHODS:
The sample consisted of 284 children, including offspring of parents with panic disorder or major depression and comparison offspring of parents without these disorders, who had been assessed with laboratory observations of temperament at ages 21 months to 6 years. We reassessed 215 of the children (77%) at 5-year follow-up (mean age 9.6 years) with structured diagnostic interviews.

RESULTS:
Compared with noninhibited, nondisinhibited control subjects, behaviorally disinhibited children had higher lifetime rates of comorbid mood plus disruptive behavior disorders and higher current rates of any disruptive behavior disorder and of oppositional defiant disorder.

CONCLUSIONS:
Behavioral disinhibition appears to be a temperamental antecedent of disruptive behavior disorders and their comorbidity with mood disorders in middle childhood, which may be targeted for preventive intervention.

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Author information

Author/s: Hirshfeld-Becker, Dina R (DR); Biederman, Joseph (J); Henin, Aude (A); Faraone, Stephen V (SV); Micco, Jamie A (JA); van Grondelle, Anne (A); Henry, Brianne (B); Rosenbaum, Jerrold F (JF);

Affiliation: Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA. dhirshfeld(-atsign-)partners.org

Grants: R01 MH 47077-11A (Agency:NIMH NIH HHS) ; R01 MH047077-14 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

Journal: Biological psychiatry (Biol Psychiatry), published in United States. (Language: eng)

Reference: 2007-Sep; vol 62 (issue 6) : pp 565-72

Dates: Created 2007/09/03; Completed 2008/01/02; Revised 2008/11/20;

PMID: 17306774, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Factors
Bipolar Disorder - epidemiology
Child
Child Behavior - psychology
Child Behavior Disorders - diagnosis; epidemiology; psychology
Child of Impaired Parents - statistics & numerical data
Child, Preschool
Comorbidity
Depressive Disorder, Major - epidemiology
Female

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