Task-induced deactivation of midline cortical regions in schizophrenia assessed with fMRI.

Full Abstract

Task-induced deactivations (TIDs) of midline cortical regions are readily observed in fMRI studies and may reflect elements of a 'default-mode' of brain function associated with self-directed mental processes at rest. In this study, we examined this TID phenomenon in schizophrenia and its relevance to patients' symptoms, task performance and level of emotional awareness. Relative to control subjects, patients showed significantly greater TID of the rostral anterior cingulate (rAC)/medial prefrontal cortex (mPFC) and precuneus (PrC)/posterior cingulate cortex (PC). The magnitude of prefrontal TIDs was associated with patients' task performance and emotional awareness for others. The nature of these associations suggests a complex interchange between cognitive and emotional influences on the resting-state activity of these prefrontal 'default mode' regions in schizophrenia.

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Author information

Author/s: Harrison, Ben J (BJ); Yücel, Murat (M); Pujol, Jesus (J); Pantelis, Christos (C);

Affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia. habj(-atsign-)unimelb.edu.au

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)

Reference: 2007-Mar; vol 91 (issue 1-3) : pp 82-6

Dates: Created 2007/03/05; Completed 2007/06/12;

PMID: 17307337, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Affect - physiology
Anxiety Disorders - diagnosis; epidemiology; psychology
Awareness - physiology
Depression - diagnosis; epidemiology; psychology
Gyrus Cinguli - physiopathology
Humans
Magnetic Resonance Imaging
Male

Male
Middle Aged
Observer Variation
Perceptual Disorders - diagnosis; epidemiology
Psychomotor Performance - physiology
Questionnaires
Reaction Time
Schizophrenia - diagnosis; epidemiology; physiopathology
Social Perception

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