Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task.

Full Abstract

Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning--previously described under conditions of negative emotion--are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing. Copyright 2007 Wiley-Liss, Inc.

Author information

Author/s: Butler, Tracy (T); Imperato-McGinley, Julianne (J); Pan, Hong (H); Voyer, Daniel (D); Cunningham-Bussel, Amy Christine (AC); Chang, Luke (L); Zhu, Yuan-Shan (YS); Cordero, Juan J (JJ); Stern, Emily (E); Silbersweig, David (D);

Affiliation: Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA. tab2006(-atsign-)med.cornell.edu

Grants: M01 RR00047 (Agency:NCRR NIH HHS) ; R01 MH0646 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)

Reference: 2007-Nov; vol 28 (issue 11) : pp 1206-12

Dates: Created 2007/10/18; Completed 2008/01/08;

PMID: 17315226, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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