Reactivation of Graves' orbitopathy after rehabilitative orbital decompression.

Full Abstract

OBJECTIVE:
To present and discuss three cases of apparent reactivation of Graves' orbitopathy (GO) after orbital decompression and to evaluate the incidence of this phenomenon.

DESIGN:
Observational case series and retrospective follow-up study.

PARTICIPANTS:
A few weeks after surgery 2 patients with GO (patients 1 and 2), treated at our institution with rehabilitative bony orbital decompression during the static phase of the disease showed clinical and radiologic evidence of reactivated orbitopathy. After this observation, a sample of 249 patients who had consecutively undergone the same treatment for the same reason before the second of the 2 observed patients was selected for this study.

METHODS:
The records of the selected patients were retrospectively reviewed searching for cases presenting with clinical and radiologic evidence of GO reactivated as a consequence of any type of bony orbital decompression. Patients treated with perioperative systemic glucocorticoids or who had concurrent periorbital diseases, injuries, or surgeries, or who had immunocompromised conditions or a follow-up of < or =2 months, were excluded.

MAIN OUTCOME MEASURES:
Incidence of reactivation. Clinical history, clinical and radiologic characteristics, treatment modalities, and time course of the reactivation in patients presenting with this phenomenon.

RESULTS:
Decompression surgery took place between 1994 and 2000. Eleven patients were excluded for having been treated with perioperative glucocorticoids. Only 1 patient (patient 3) presented with reactivation. The incidence of the phenomenon that we regard as reactivation of GO after rehabilitative bony orbital decompression was therefore 1.3% (3/239). In all 3 patients, the reactivation took place a few weeks after surgery, after an early normal convalescence period and could be controlled with systemic immunosuppression or orbital radiotherapy. None of the patients we report developed further episodes of reactivation during the follow-up period (mean, 7.5 years).

CONCLUSIONS:
Based on its clinical characteristics, we suggest naming our observation delayed decompression-related reactivation and we propose using its acronym DDRR when referring to it. Although DDRR appears to be a rare event, it is important for physicians and patients to be aware of its possible occurrence with rehabilitative decompression surgery.

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Author information

Author/s: Baldeschi, Lelio (L); Lupetti, Antonella (A); Vu, Phung (P); Wakelkamp, Iris M M J (IM); Prummel, Mark F (MF); Wiersinga, Wilmar M (WM);

Affiliation: Orbital Center, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands. l.baldeschi(-atsign-)amc.uva.nl

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: Ophthalmology (Ophthalmology), published in United States. (Language: eng)

Reference: 2007-Jul; vol 114 (issue 7) : pp 1395-402

Dates: Created 2007/07/06; Completed 2007/07/31;

PMID: 17320178, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Decompression, Surgical - adverse effects
Female
Follow-Up Studies
Glucocorticoids - therapeutic use
Graves Ophthalmopathy - pathology; radiography; surgery; therapy
Humans
Immunosuppression
Incidence

Methylprednisolone - therapeutic use
Middle Aged
Orbit - surgery
Prednisone - therapeutic use
Radiotherapy
Recurrence
Reoperation
Retrospective Studies
Tomography, X-Ray Computed

Associated Chemicals: Glucocorticoids (0) ; Prednisone (53-03-2) ; Methylprednisolone (83-43-2)

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