Progress in the molecular biology of malaria and the immunology of nematode infections.

Full Abstract

Japan is one of a small number of countries to have successfully controlled or eliminated major parasitic diseases, including malaria, filariasis, schistosomiasis and enteric parasitoses. Of particular importance in this success was a close collaboration between primary research and public health efforts. Many Japanese researchers continue to study malaria, particularly the areas of genetics and immunology, and this should contribute to global parasite eradication strategies. Furthermore, studies of immunoregulation of nematode infection using the interleukin-18 pathway, most of which have been conducted in Japan, are helping to improve researchers' understanding of human immune mechanisms and host-parasite interactions.

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Author information

Author/s: Arizono, Naoki (N); Nakanihsi, Kenji (K); Horii, Toshihiro (T); Tanabe, Kazuyuki (K);

Affiliation: Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan. arizonon(-atsign-)koto.kpu-m.ac.jp

Journal and publication information

Publication Type: Journal Article; Review

Journal: Trends in parasitology (Trends Parasitol), published in England. (Language: eng)

Reference: 2007-Apr; vol 23 (issue 4) : pp 175-81

Dates: Created 2007/03/26; Completed 2007/06/07; Revised 2008/11/21;

PMID: 17320481, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Antigenic Variation
Antigens, Protozoan - immunology
Humans
Immunity, Innate - physiology
Interleukin-18 - immunology
Interleukin-2 - immunology
Japan

Malaria - immunology; parasitology; prevention & control
Malaria Vaccines - therapeutic use
Mice
Models, Immunological
Nematode Infections - immunology; parasitology; prevention & control
Plasmodium - genetics; pathogenicity
Strongyloides - immunology; pathogenicity
Vanuatu

Associated Chemicals: Antigens, Protozoan (0) ; Interleukin-18 (0) ; Interleukin-2 (0) ; Malaria Vaccines (0)

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