Research article summary (published 21 Feb 2007):

Variability of visual field measurements is correlated with the gradient of visual sensitivity.

Full Abstract

Conventional static automated perimetry provides important clinical information, but its utility is limited by considerable test-retest variability. Fixational eye movements during testing could contribute to variability. To assess this possibility, it is important to know how much sensitivity change would be caused by a given eye movement. To investigate this, we have evaluated the gradient, the rate at which sensitivity changes with location. We tested one eye each, twice within 3 weeks, of 29 patients with glaucoma, 17 young normal subjects and 13 older normal subjects. The 10-2 test pattern with the SITA Standard algorithm was used to assess sensitivity at locations with 2 degrees spacing. Variability and gradient were calculated at individual test locations. Matrix correlations were determined between variability and gradient, and were substantial for the patients with glaucoma. The results were consistent with a substantial contribution to test-retest variability from small fixational eye movements interacting with visual field gradient. Successful characterization of the gradient of sensitivity appears to require sampling at relatively close spacing, as in the 10-2 test pattern.

Author information

Author/s: Wyatt, Harry J (HJ); Dul, Mitchell W (MW); Swanson, William H (WH);

Affiliation: Department of Biological Sciences, State University of New York, State College of Optometry, New York, NY 10036, USA. wyatt(-atsign-)sunyopt.edu

Grants: R01 EY007716-15 (Agency:NEI NIH HHS) ; R01 EY007716-16 (Agency:NEI NIH HHS) ; R01 EY007716-17 (Agency:NEI NIH HHS) ; R01 EY007716-18 (Agency:NEI NIH HHS) ; R01-EY007716 (Agency:NEI NIH HHS) ; R03-EY014549 (Agency:NEI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Vision research (Vision Res), published in England. (Language: eng)

Reference: 2007-Mar; vol 47 (issue 7) : pp 925-36

Dates: Created 2007/03/12; Completed 2007/06/29; Revised 2008/11/20;

PMID: 17320924, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Contrast Sensitivity - physiology Eye Movements - physiology Fixation, Ocular - physiology Glaucoma - physiopathology

Humans Middle Aged Perimetry - methods Reproducibility of Results Visual Fields - physiology Visual Perception - physiology

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