Delayed vomiting in children with cancer after receiving moderately high or highly emetogenic chemotherapy.

Full Abstract

Delayed vomiting is a potentially significant adverse effect of chemotherapy used to treat childhood cancer, but little is known about the experience of delayed vomiting in children and adolescents. An exploratory study was conducted to determine the pattern of delayed vomiting in children and adolescents with cancer after highly emetic chemotherapy and to identify possible risk factors. In a sample of 82 children and adolescents who completed 117 cycles of highly emetic chemotherapy, the overall prevalence of delayed vomiting was 32%. The frequency of delayed vomiting was highest on delayed day 2, with 21% of participants experiencing vomiting. By delayed day 7, only 9% of participants still reported vomiting. The severity of vomiting was moderate to severe in 11% to 12% of subjects. Age and gender had no significant effect on delayed vomiting. The emetic potential of the agent, incomplete protection from acute vomiting, and treatment regimens that lasted 6 or more days significantly affected delayed vomiting. In addition, a history of motion sickness, lack of acute control, and 6 or more days of chemotherapy were predictive of delayed vomiting.

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Author information

Author/s: Robinson, Deborah L (DL); Carr, Barbara A (BA);

Affiliation: Pediatric Oncology, St Louis Children's Hospital, St Louis, MO 63110, USA. dlr3005(-atsign-)bjc.org

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses (J Pediatr Oncol Nurs), published in United States. (Language: eng)

Reference: -2007 Mar-Apr; vol 24 (issue 2) : pp 70-80

Dates: Created 2007/03/02; Completed 2007/05/04;

PMID: 17332421, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Activities of Daily Living - psychology
Adolescent
Antineoplastic Agents - adverse effects
Appetite
Attitude to Health
Child
Child, Preschool
Female
Humans
Infant
Logistic Models
Male
Midwestern United States - epidemiology

Midwestern United States - epidemiology
Multivariate Analysis
Neoplasms - drug therapy
Nurse's Role
Nursing Methodology Research
Oncologic Nursing
Prevalence
Prospective Studies
Quality of Life - psychology
Questionnaires
Risk Factors
Time Factors
Vomiting - chemically induced; complications; epidemiology; prevention & control; psychology

Associated Chemicals: Antineoplastic Agents (0)

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