dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma(1) receptor activation in the rat.

Full Abstract

An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to 3 microg/kg given subcutaneously dose-dependently attenuated the morphine-produced conditioned place preference. However, dextro-morphine at a higher dose 100 microg/kg did not affect the morphine-produced conditioned place preference. Thus, dextro-morphine pretreatment induces a U-shaped dose-response curve for attenuating the morphine-produced conditioned place preference. The attenuation of the morphine-produced conditioned place preference was reversed by the pretreatment with the sigma(1) receptor antagonist BD1047 (N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. dextro-Morphine or BD1047 given alone did not affect the baseline place conditioning. It is concluded that dextro-morphine attenuated the morphine-produced conditioned place preference via the sigma(1) receptor activation.

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Author information

Author/s: Wu, Hsiang-en (HE); Schwasinger, Emma T (ET); Terashvili, Maia (M); Tseng, Leon F (LF);

Affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Grants: DA12588 (Agency:NIDA NIH HHS) ; R01 DA012588-05 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2007-May; vol 562 (issue 3) : pp 221-6

Dates: Created 2007/04/17; Completed 2007/06/21; Revised 2008/11/20;

PMID: 17335800, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesics, Opioid - pharmacology
Analysis of Variance
Animals
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Ethylenediamines
Injections, Intraperitoneal

Injections, Subcutaneous
Male
Morphine - pharmacology
Rats
Receptors, sigma - drug effects; metabolism
Reward
Stereoisomerism

Associated Chemicals: Analgesics, Opioid (0) ; Ethylenediamines (0) ; Receptors, sigma (0) ; sigma-1 receptor (0) ; BD 1047 (138356-20-4) ; Morphine (57-27-2)

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