Arousal modulation in females with fragile X or Turner syndrome.

Full Abstract

The present study was carried out to examine physiological arousal modulation (heart activity and skin conductance, across baseline and cognitive tasks, in females with fragile X or Turner syndrome and a comparison group of females with neither syndrome. Relative to the comparison group, for whom a greater increase in skin conductance was associated with poor arithmetic performance and less risk taking behavior, females with fragile X displayed a minimal increase in heart activity that was nevertheless associated with poor performance on mental arithmetic. In contrast, no arousal-cognitive performance relationship emerged for the group with Turner syndrome. Taken together, our findings suggest that distinct profiles of arousal modulation might be associated with cognitive deficits in these syndrome populations.

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Author information

Author/s: Roberts, Jane (J); Mazzocco, Michèle M M (MM); Murphy, Melissa M (MM); Hoehn-Saric, Rudolf (R);

Affiliation: Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Grants: P30-HD003110-38S1 (Agency:NICHD NIH HHS) ; P30-HD40602-01 (Agency:NICHD NIH HHS) ; P50 NS35359 (Agency:NINDS NIH HHS) ; R01 HD034061 (Agency:NICHD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Journal of autism and developmental disorders (J Autism Dev Disord), published in United States. (Language: eng)

Reference: 2008-Jan; vol 38 (issue 1) : pp 20-7

Dates: Created 2008/01/07; Completed 2008/05/30;

PMID: 17340202, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Arousal - physiology
Cognition Disorders - diagnosis; epidemiology
Female
Fragile X Syndrome - genetics; physiopathology; psychology
Galvanic Skin Response - physiology

Galvanic Skin Response - physiology
Heart Rate - physiology
Humans
Neuropsychological Tests
Point Mutation - genetics
Severity of Illness Index
Turner Syndrome - genetics; physiopathology; psychology

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