Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.

Full Abstract

Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA.

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Author information

Author/s: Bresnihan, Barry (B); Gerlag, Danielle M (DM); Rooney, Terence (T); Smeets, Tom J M (TJ); Wijbrandts, Carla A (CA); Boyle, David (D); Fitzgerald, Oliver (O); Kirkham, Bruce W (BW); McInnes, Iain B (IB); Smith, Malcolm (M); Ulfgren, Ann-Kristin (AK); Veale, Douglas J (DJ); Tak, Paul P (PP);

Affiliation: Department of Rheumatology, St. Vincent's University Hospital, and The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. B.Bresnihan(-atsign-)svcpc.ie

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: The Journal of rheumatology (J Rheumatol), published in Canada. (Language: eng)

Reference: 2007-Mar; vol 34 (issue 3) : pp 620-2

Dates: Created 2007/03/08; Completed 2007/04/10;

PMID: 17343309, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Arthritis, Rheumatoid - therapy
Biological Markers
Humans

Humans
Macrophages - cytology
Predictive Value of Tests
Reproducibility of Results
Synovial Membrane - cytology; immunology

Associated Chemicals: Antigens, CD (0) ; Antigens, Differentiation, Myelomonocytic (0) ; Biological Markers (0) ; CD68 antigen, human (0)

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