Measurement of the subjective effects of methylphenidate in 11- to 15-year-old children with attention-deficit/hyperactivity disorder.

Full Abstract

OBJECTIVE:
This study examined subjective and other behavioral effects of methylphenidate (MPH) among adolescents.

METHODS:
Standard abuse liability assessment methods that have been used in adult populations were modified for attention-deficit/hyperactivity disorder (ADHD) adolescents. MPH effects (0, 0.25 mg/kg) were evaluated under randomized, double-blind conditions in two 5-hour laboratory sessions in 24 (13 female) 11-15 year olds diagnosed with ADHD.

RESULTS:
Repeated measures analysis of covariance indicated significant dose and dose by time interactions on subjective ratings on the modified amphetamine (A) [F (1, 20) = 5.98; p < 0.05; eta2 = 0.36], morphine-benzedrine group (MBG) [F (1, 21) = 8.93 p < 0.01; eta2 = 0.38] and benzedrine group scale (BG) [F (1, 21) + 13.10 p < 0.01; eta2 = 0.37] scales of the Addiction Research Center Inventory; "Hungry" and "How sure are you that you got the medication today?" from the Visual Analogue Scale, the Profile of Mood States Depression scale, performance on the Continuous Performance Task, heart rate and blood pressure, and level of activity.

CONCLUSIONS:
This is the first study to document subjective effects of stimulants in adolescents with ADHD that have been associated with drug abuse potential in adults. There are increasing concerns about nontherapeutic stimulant use in adolescents and young adults. Assessing subjective effects of pharmacotherapies for ADHD along with other measures of abuse potential such as drug self-administration may aid in assessing the therapeutic effects and/or risk of medications used in the treatment of ADHD.

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Author information

Author/s: Martin, Catherine A (CA); Guenthner, Greg (G); Bingcang, Christopher (C); Rayens, Mary Kay (MK); Kelly, Thomas H (TH);

Affiliation: Department of Psychiatry, University of Kentucky College of Medicine, Lexington, Kentucky 40509, USA. cmartin(-atsign-)uky.edu

Grants: 1 K08 DA00333 (Agency:NIDA NIH HHS) ; 1 R03 DA015413-01A2 (Agency:NIDA NIH HHS) ; M01 RR02602 (Agency:NCRR NIH HHS) ; P50 DA05312 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal: Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol), published in United States. (Language: eng)

Reference: 2007-Feb; vol 17 (issue 1) : pp 63-73

Dates: Created 2007/03/08; Completed 2007/05/30; Revised 2007/12/03;

PMID: 17343554, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Arousal - drug effects
Attention Deficit Disorder with Hyperactivity - drug therapy; psychology
Attitude to Health
Central Nervous System Stimulants - adverse effects; therapeutic use
Child
Double-Blind Method

Female
Humans
Male
Methylphenidate - adverse effects; therapeutic use
Pain Measurement
Questionnaires
Self Disclosure

Associated Chemicals: Central Nervous System Stimulants (0) ; Methylphenidate (113-45-1)

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