[Effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation]

Full Abstract

OBJECTIVE:
To explore the effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation.

METHODS:
Male Sprague-Dawley rats were used as donors and recipients of orthotopic liver transplantation (OLT), and were randomly divided into extract of ginkgo biloba leaves group (Egb), NS control group (NS), and sham operation group (SO) according to whether the extract of ginkgo biloba leaves was injected by the venous (40 mg/kg) 1 h before the liver grafts harvesting. The rats were killed at 2 h, 6 h, and 24 h after the ischemia/reperfusion. The serum concentrations of ALT and AST were determined and the liver tissue were sampled to observe the expression of TNF-alpha and IL-1.

RESULTS:
After the ischemia/reperfusion the serum concentration of ALT and AST and expressions of TNF-alpha and IL-1 in the hepatic tissue in the NS group significantly increased (p<0.01), and the hepatocytic morphologic change was obvious compared with the SO group. The treatment of ginkgo biloba extract significantly decreased the serum concentration of ALT and AST and the expressions of TNF-alpha and IL-1 in the hepatic tissue in EGb group compared with the NS group (p<0.01), and relieved the hepatocyte swelling and necrosis.

CONCLUSION:
Ginkgo bilobA extract may decrease the release of TNF-alpha and IL-1 by inhibiting activation of kuffer cells and regulate the cell factors to protect the live.

Learn Faster Today Improve your study skills

Author information

Author/s: Zhou, Jie-Bin (JB); Yang, Xue-Kang (XK); Ye, Qi-Fa (QF); Ming, Ying-Zi (YZ); Xia, Zong-Jiang (ZJ);

Affiliation: Institute of Organ Transplantation, Third Xiangya Hospital, Central South University, Department of General Surgery, Changsha Central Hospital, Changsha 410013, China. zhoujiebin2003(-atsign-)163.com

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban), published in China. (Language: chi)

Reference: 2007-Feb; vol 32 (issue 1) : pp 54-8

Dates: Created 2007/03/08; Completed 2008/05/01;

PMID: 17344587, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Drugs, Chinese Herbal - pharmacology
Ginkgo biloba - chemistry
Interleukin-1 - biosynthesis
Liver - blood supply; drug effects; metabolism
Liver Transplantation

Liver Transplantation
Male
Plant Leaves - chemistry
Random Allocation
Rats
Rats, Sprague-Dawley
Reperfusion Injury - blood; metabolism; prevention & control
Tumor Necrosis Factor-alpha - biosynthesis

Associated Chemicals: Drugs, Chinese Herbal (0) ; Interleukin-1 (0) ; Tumor Necrosis Factor-alpha (0) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)

These are the highest related articles currently in the database:

See 100+ related articles.