Impairment of spatial memory consolidation in APP(751SL) mice results in cue-guided response.

Full Abstract

APP(751SL) mice of 5-6- and 7-8-month-old and their wild-type littermates were submitted to one-session learning in a water-maze with three levels of training (4, 12 or 22 trials). Training consisted in finding a submerged platform with a fixed location and marked by a cue. During testing two platforms were presented:
one consistent with the spatial location allowing place-response (PR) and the other signaled by the cue enabling cued-response (CR). When testing occurred 24h after training, wild-type and 5-6-month-old APP(751SL) mice exhibited a shift in response strategy as a function of training level, by executing CR when trained with 4 trials and PR when trained with 12 trials, but 7-8-month-old APP(751SL) mice executed only CR. However, they displayed PR when tested 1h after 12- and 22-trial, suggesting a consolidation deficit. Zif268 imaging showed plasticity impairment of the hippocampal-dependent memory system but not of the dorsolateral caudate nucleus. Moreover, in these APP(751SL) mice, the deficit selectively affecting hippocampal function cannot be directly related to the onset of beta-amyloid deposits.

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Author information

Author/s: Blanchard, J (J); Martel, G (G); Guillou, J-L (JL); Noguès, X (X); Micheau, J (J);

Affiliation: Laboratory of Cognitive Neuroscience, CNRS UMR 5106, University of Bordeaux I, Avenue des Facultés, 33405 Talence Cedex, France.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurobiology of aging (Neurobiol Aging), published in United States. (Language: eng)

Reference: 2008-Jul; vol 29 (issue 7) : pp 1011-21

Dates: Created 2008/05/26; Completed 2008/06/20;

PMID: 17350733, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alzheimer Disease - metabolism
Amyloid beta-Protein Precursor - genetics; metabolism
Animals
Cues
Disease Models, Animal
Humans

Associated Chemicals: Amyloid beta-Protein Precursor (0)

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