KIBRA gene variants are associated with episodic memory in healthy elderly.

Full Abstract

The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an in-depth characterized sample of healthy elderly subjects. The effectsizes of the respective KIBRA SNP on memory even exceed those of the initial report. In parallel to the first study, the effect is restricted to hippocampus-related episodic memory without effects on frontal lobe function. The impact of KIBRA on memory is most likely of high relevance in elderly subjects as it is in young.

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Author information

Author/s: Schaper, K (K); Kolsch, H (H); Popp, J (J); Wagner, M (M); Jessen, F (F);

Affiliation: Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurobiology of aging (Neurobiol Aging), published in United States. (Language: eng)

Reference: 2008-Jul; vol 29 (issue 7) : pp 1123-5

Dates: Created 2008/05/26; Completed 2008/06/20;

PMID: 17353070, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cognition - physiology
Female
Humans
Male
Memory - physiology

Middle Aged
Mutation - genetics
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Variation (Genetics) - genetics

Associated Chemicals: Proteins (0) ; WWC1 protein, human (0)

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