Research article summary (published 27 Feb 2007):

Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis.

Full Abstract

OBJECTIVE: To investigate whether patients with early primary progressive multiple sclerosis show changes in T1 relaxation time (T1-RT) in normal-appearing white matter (NAWM) and normal-appearing gray matter (NAGM) during 2 years and whether T1-RT at baseline predicts disability. METHODS: Twenty-one patients and 12 control subjects were studied at baseline and after 2 years. Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC) scores were assessed. T1 relaxation time histograms of NAWM and NAGM were obtained in all subjects, and mean, peak height, and peak location of the histograms were measured. Paired t tests were used to compare baseline and 2-year histogram values in patients and control subjects. To investigate whether T1-RT predicted clinical changes, multiple linear regression analysis was used. RESULTS: Patients showed increases in NAWM and NAGM T1-RT mean and peak location during follow-up, and significant decreases in NAWM and NAGM peak height. Baseline NAWM T1-RT mean values and peak height predicted disability at 2 years, as measured with the Multiple Sclerosis Functional Composite score. CONCLUSION: T1 relaxometry is a good marker of disease progression and has prognostic potential in primary progressive multiple sclerosis.

Author information

Author/s: Manfredonia, Francesco (F); Ciccarelli, Olga (O); Khaleeli, Zhaleh (Z); Tozer, Daniel J (DJ); Sastre-Garriga, Jaume (J); Miller, David H (DH); Thompson, Alan J (AJ);

Affiliation: Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, England.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Archives of neurology (Arch Neurol), published in United States. (Language: eng)

Reference: 2007-Mar; vol 64 (issue 3) : pp 411-5

Dates: Created 2007/03/13; Completed 2007/04/24;

PMID: 17353385, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Disability Evaluation Disease Progression Female Humans Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging - methods

Magnetic Resonance Imaging - methods Male Middle Aged Multiple Sclerosis, Chronic Progressive - pathology Predictive Value of Tests Relaxation - physiology Severity of Illness Index Statistics, Nonparametric

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