Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents.

Full Abstract

AIM:
The protective effects of Ginkgo biloba phytosomes (GBP) on carbon tetrachloride (CCl4)-induced hepatotoxicity and the probable mechanism(s) involved in this protection were investigated in rats.

METHODS:
Liver damage was induced in Wistar rats by administering a 1:1 (v/v) mixture of CCl4 and olive oil (1 ml/kg, i.p.) once daily for 7 days. GBP at 25 mg/kg and 50 mg/kg, i.p. and reference drug silymarin (200 mg/kg, p.o.) were administered for 10 days to CCl4-treated rats, this treatment beginning 3 days prior to the commencement of CCl4 administration. The degree of protection was evaluated by determining the marker enzymes (SGOT, SGPT and SALP), albumin (Alb) and total proteins (TP). Further, the effects of GBP on lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were estimated in liver homogenates to evaluate antioxidant activity.

RESULTS:
GBP (25 and 50 mg/kg) and silymarin elicited significant hepatoprotective activity by decreasing the activities of serum marker enzymes and lipid peroxidation and elevated the levels of GSH, SOD, CAT, GPX, GR, Alb and TP in a dose-dependent manner.

CONCLUSION:
The present findings indicate that the hepatoprotective effects of GBP against CCl4-induced oxidative damage may be due to its antioxidant and free radical-scavenging activity.

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Author information

Author/s: Naik, Suresh R (SR); Panda, Vandana S (VS);

Affiliation: Sinhgad Institute of Pharmaceutical Sciences, Lonavala, India.

Journal and publication information

Publication Type: Journal Article

Journal: Liver international : official journal of the International Association for the Study of the Liver (Liver Int), published in England. (Language: eng)

Reference: 2007-Apr; vol 27 (issue 3) : pp 393-9

Dates: Created 2007/03/14; Completed 2007/06/22;

PMID: 17355462, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Antioxidants - pharmacology
Carbon Tetrachloride Poisoning - metabolism; pathology
Dose-Response Relationship, Drug
Ginkgo biloba - chemistry
Lipid Peroxidation - drug effects
Liver - drug effects; metabolism; pathology

Liver - drug effects; metabolism; pathology
Mice
Plant Extracts - pharmacology
Protective Agents - pharmacology
Rats
Rats, Wistar
Silymarin - pharmacology

Associated Chemicals: Antioxidants (0) ; Plant Extracts (0) ; Protective Agents (0) ; Silymarin (0)

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