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| Research article summary (published 30 May 2006): |
Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue.
Full Abstract
Secretion of IL-1alpha, IL-1beta, IL-6, IL-10, and TNF-alpha cytokines by villous chorion cultures (7-14 weeks) during normal pregnancy and in spontaneous abortions was studied. Secretion of IL-1alpha and IL-6 increased 4.5 and 7.3 times in miscarriages, while secretion of IL-1beta, IL-10, and TNF-alpha decreased. LPS stimulated the production of IL-1alpha and IL-6 in samples obtained during surgical abortion. LPS stimulated IL-1alpha and TNF-alpha secretion in miscarriages, while the level of IL-6 production decreased significantly. It is hypothesized that increased production of IL-1alpha and IL-6 and attenuation of the antiinflammatory effect of IL-10 play an important role in the pathogenesis of miscarriages at early stages of gestation. The results suggest that cytokine regulation of the fetus rejection is different at early and late stages of gestation.
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Author information
Author/s: Pavlov, O V (OV); Lalayan, D V (DV); Sel'kov, S A (SA);
Affiliation: Laboratory of Immunology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med), published in United States. (Language: eng)
Reference: 2006-Jun; vol 141 (issue 6) : pp 720-3
Dates: Created 2007/03/16; Completed 2007/04/27;
PMID: 17364059, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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