Research article summary (published 30 Dec 2006):

Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.

Full Abstract

The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured:
body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA1c, FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event.

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Author information

Author/s: Derosa, Giuseppe (G); Cicero, Arrigo F G (AF); Scalise, Filippo (F); Avanzini, Maria A (MA); Tinelli, Carmine (C); Piccinni, Mario N (MN); Peros, Emmanouil (E); Geroldi, Diego (D); Fogari, Elena (E); D'Angelo, Angela (A);

Affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. giuseppe.derosa(-atsign-)unipv.it

Journal and publication information

Publication Type: Journal Article; Multicenter Study

Journal: Endothelium : journal of endothelial cell research (Endothelium), published in United States. (Language: eng)

Reference: -2007 Jan-Feb; vol 14 (issue 1) : pp 45-51

Dates: Created 2007/03/16; Completed 2007/06/06;

PMID: 17364896, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acute Disease Aged Apolipoproteins A - blood Blood Glucose - analysis Blood Pressure Body Mass Index C-Reactive Protein - analysis Case-Control Studies Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Disease - complications; pathology Diabetes Mellitus, Type 2 - blood; complications; enzymology Fasting

Female Hemoglobin A, Glycosylated - analysis; metabolism Homocysteine - blood Humans Insulin - blood Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Middle Aged Plasminogen Activator Inhibitor 1 - blood Syndrome Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-2 - blood Triglycerides - blood

Associated Chemicals: Apolipoproteins A (0) ; Blood Glucose (0) ; Cholesterol, HDL (0) ; Cholesterol, LDL (0) ; Hemoglobin A, Glycosylated (0) ; Plasminogen Activator Inhibitor 1 (0) ; Tissue Inhibitor of Metalloproteinase-1 (0) ; Triglycerides (0) ; Insulin (11061-68-0) ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Homocysteine (454-28-4) ; Cholesterol (57-88-5) ; C-Reactive Protein (9007-41-4) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)

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