HIV related and non-HIV related mortality before and after the introduction of highly active antiretroviral therapy (HAART) in Norway compared to the general population.

Full Abstract

The objective of the study was to compare the mortality in HIV infected individuals to the general population, and to explore the relative contribution of HIV to mortality before and after the introduction of highly active antiretroviral therapy (HAART). All HIV patients attending Ullevål University Hospital, Oslo, Norway before (cohort 1) and after (cohort 2) the introduction of HAART were included. Causes of deaths were classified as HIV related or not. Mortality in the Norwegian general population was standardized according to the distribution of age and gender in our cohorts. Ratios between mortality in our cohorts and the standardized mortality were calculated. The risk ratio (RR) for 5-y mortality compared to the general population was 22.6 (95% confidence interval (CI), 19.5-26.4) in cohort 1 (n = 782), and 3.96 (95% CI 2.25-6.97) in cohort 2 (n = 398). The non-HIV related mortality RR was 4.42 (95% CI 3.18-6.13) in cohort1 and 0.89 (95% CI 0.29-2.76) in cohort 2. Higher age and low CD4 cell count were associated with increased mortality. Thus, in the HAART era the mortality in HIV patients was reduced by 80%. However, the mortality in the HAART era was still 4 times higher than in the general population.

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Author information

Author/s: Ormaasen, Vidar (V); Sandvik, Leiv (L); Dudman, Susanne G (SG); Bruun, Johan N (JN);

Affiliation: Department of Infectious Diseases, Ullevål University Hospital, Oslo, Norway. vidar.ormaasen(-atsign-)medisin.uio.no

Journal and publication information

Publication Type: Journal Article

Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis), published in Sweden. (Language: eng)

Reference: 2007-; vol 39 (issue 1) : pp 51-7

Dates: Created 2007/03/16; Completed 2007/04/10;

PMID: 17366013, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

AIDS-Related Opportunistic Infections - mortality
Adolescent
Adult
Aged
Aged, 80 and over
Antiretroviral Therapy, Highly Active - statistics & numerical data
Child
Child, Preschool
Female
HIV Infections - drug therapy; mortality

HIV Infections - drug therapy; mortality
Humans
Infant
Male
Middle Aged
Mortality - trends
Norway - epidemiology
Population Surveillance
Risk
Survival Analysis

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