Embryology and epidemiology of cleft lip and palate.

Full Abstract

Craniofacial anomalies, in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. This article reviews the embryology of the face, lip, and palate to enhance the understanding of the pathogenesis of these lesions, with particular attention to the period of susceptibility during gestation, complexity, and the factors that may influence their development. It includes an overview of the prevalence and environmental and genetic causes of cleft lip-with or without cleft palate- and cleft palate.

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Author information

Author/s: Bernheim, N (N); Georges, M (M); Malevez, C (C); De Mey, A (A); Mansbach, A (A);

Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, The Cleft Lip and Palate Team, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. nathalie.bernheim(-atsign-)huderf.be

Journal and publication information

Publication Type: Journal Article

Journal: B-ENT (B-ENT), published in Belgium. (Language: eng)

Reference: 2006-; vol 2 Suppl 4 (issue ) : pp 11-9

Dates: Created 2007/03/19; Completed 2007/04/03;

PMID: 17366840, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cleft Lip - embryology; epidemiology; genetics
Cleft Palate - embryology; epidemiology; genetics
Disease Susceptibility
Embryonic Development
Face - embryology

Humans
Lip - embryology
Palate - embryology
Prevalence
Risk Factors

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