Conjugated linoleic acids promote human fat cell apoptosis.

Full Abstract

Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Some isomers have been shown to reduce fat mass in animal and cell culture models. However, controversial results were obtained in studies of supplementation of CLAs in human subjects. In order to get more insights into the direct effects of CLAs on human fat cells, we have studied the influence of cis-9, trans-11 CLA and trans-10, cis-12 CLA on the biology of human SGBS preadipocytes and adipocytes. Both CLA isomers equally inhibited the proliferation of preadipocytes in a dose-dependent manner. Continuous treatment with 1-10 microM trans-10, cis-12 CLA, and to a weaker extent cis-9, trans-11 CLA, inhibited accumulation of lipids during adipogenic differentiation. Treatment with higher doses of CLA induced apoptosis in preadipocytes, in differentiating cells, and adipocytes. The trans-10, cis-12 isomer had a higher apoptotic potency in adipocytes than cis-9, trans-11 CLA. Taken together, the treatment of human preadipocytes and adipocytes with physiological relevant concentrations of CLAs resulted in an impairment of proliferation and differentiation and induction of apoptosis. The trans-10, cis-12 isomer was more potent than the cis-9, trans-11 isomer. Further clinical studies are needed to evaluate the effects of CLAs on human fat mass and metabolism in vivo.

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Author information

Author/s: Fischer-Posovszky, P (P); Kukulus, V (V); Zulet, M A (MA); Debatin, K M (KM); Wabitsch, M (M);

Affiliation: Department of Pediatrics and Adolescent Medicine, University of Ulm, 89075 Ulm, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme (Horm Metab Res), published in Germany. (Language: eng)

Reference: 2007-Mar; vol 39 (issue 3) : pp 186-91

Dates: Created 2007/03/21; Completed 2007/05/24; Revised 2007/07/24;

PMID: 17373632, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adipocytes - cytology; drug effects
Adipogenesis - drug effects
Apoptosis - drug effects
Cell Proliferation - drug effects

Cell Proliferation - drug effects
Cells, Cultured
Humans
Linoleic Acids, Conjugated - pharmacology

Associated Chemicals: Linoleic Acids, Conjugated (0) ; cis-9, trans-11-conjugated linoleic acid (0) ; trans-10,cis-12-conjugated linoleic acid (0)

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