Changes in fMRI activation following rehabilitation of reading and visual processing deficits in subjects with traumatic brain injury.

Full Abstract

In this case series fMRI was used to examine activation patterns during presentation of a reading comprehension (RC) task in three adult subjects with a history of severe traumatic brain injury (TBI). These subjects received cognitive rehabilitation therapy (CRT) for visual processing and acquired reading deficits. fMRI and neuropsychological testing occurred pre- and post-rehabilitation. The study's objective was to evaluate the neurobiological changes using fMRI occurring with CRT and to compare these results to repeat fMRI in matched controlsubjects. While improvements in neuropsychologicaltesting occurred post-CRT, diffuse and variable activation patterns in the subjects with TBI were still demonstrated when compared to the control subjects repeat imaging. Multiple networks exist to accomplish the complex task of sentence reading and rehabilitation of the cognitive components of reading, such as visual processing; in subjects with TBI, can alter the activation pattern demonstrated during reading comprehension in subjects many years post-injury. This is the first demonstration of changes in network activation patterns post-CRT in patients with severe, chronic TBI on an fMRI task shown to have imaging stability in a normal control sample.

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Author information

Author/s: Laatsch, Linda (L); Krisky, Christine (C);

Affiliation: University of Illinois, College of Medicine, Department of Rehabilitation and Neurology, M/C 888 912 S. Wood, Chicago, IL 60612, USA. llaatsch(-atsign-)uic.edu

Journal and publication information

Publication Type: Journal Article

Journal: Brain injury : [BI] (Brain Inj), published in England. (Language: eng)

Reference: 2006-Dec; vol 20 (issue 13-14) : pp 1367-75

Dates: Created 2007/03/23; Completed 2007/11/20;

PMID: 17378228, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Attention
Brain - physiopathology
Brain Injury, Chronic - physiopathology; psychology; rehabilitation
Case-Control Studies
Cognitive Therapy - methods
Comprehension
Female

Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Pattern Recognition, Visual
Perceptual Disorders - etiology; physiopathology; rehabilitation
Reading

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