Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry.

Full Abstract

BACKGROUND:
Tumor markers are becoming increasingly important in breast cancer research because of their impact on prognosis, treatment, and survival, and because of their relation to breast cancer subtypes. The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer.

METHODS:
Using the population-based California Cancer Registry data, we identified women diagnosed with triple-negative breast cancer between 1999 and 2003. We examined differences between triple-negative breast cancers compared with other breast cancers in relation to age, race/ethnicity, socioeconomic status (SES), stage at diagnosis, tumor grade, and relative survival.

RESULTS:
A total of 6370 women were identified as having triple-negative breast cancer and were compared with the 44,704 women with other breast cancers. Women with triple-negative breast cancers were significantly more likely to be under age 40 (odds ratio [OR], 1.53), and non-Hispanic black (OR, 1.77) or Hispanic (OR, 1.23). Regardless of stage at diagnosis, women with triple-negative breast cancers had poorer survival than those with other breast cancers, and non-Hispanic black women with late-stage triple-negative cancer had the poorest survival, with a 5-year relative survival of only 14%.

CONCLUSIONS:
Triple-negative breast cancers affect younger, non-Hispanic black and Hispanic women in areas of low SES. The tumors were diagnosed at later stage and were more aggressive, and these women had poorer survival regardless of stage. In addition, non-Hispanic black women with late-stage triple-negative breast cancer had the poorest survival of any comparable group.Copyright (c) 2007 American Cancer Society

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Author information

Author/s: Bauer, Katrina R (KR); Brown, Monica (M); Cress, Rosemary D (RD); Parise, Carol A (CA); Caggiano, Vincent (V);

Affiliation: Public Health Institute/California Cancer Registry, Sacramento, California 95815-4402, USA. kbauer(-atsign-)ccr.ca.gov

Grants: N01-PC-35136 (Agency:NCI NIH HHS) ; N01-PC-35139 (Agency:NCI NIH HHS) ; N02-PC-15105 (Agency:NCI NIH HHS) ; U55/CCR921930-02 (Agency:PHS HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Cancer (Cancer), published in United States. (Language: eng)

Reference: 2007-May; vol 109 (issue 9) : pp 1721-8

Dates: Created 2007/05/24; Completed 2007/06/26; Revised 2007/12/03;

PMID: 17387718, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
African Americans
Age Factors
Age of Onset
Aged
Aged, 80 and over
Breast Neoplasms - ethnology; metabolism; mortality
California
Ethnic Groups
Female
Hispanic Americans

Humans
Middle Aged
Phenotype
Receptor, erbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Registries
Risk Factors
Socioeconomic Factors
Survival Analysis
Survival Rate

Associated Chemicals: Receptors, Estrogen (0) ; Receptors, Progesterone (0) ; Receptor, erbB-2 (EC 2.7.1.112)

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