Research article summary (published 7 Feb 2007):

Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Full Abstract

The current marine pharmacology review that covers the peer-reviewed literature during 2003 and 2004 is a sequel to the authors' 1998-2002 reviews, and highlights the preclinical pharmacology of 166 marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis or antiviral activities were reported for 67 marine chemicals. Additionally 45 marine compounds were shown to have significant effects on the cardiovascular, immune and nervous system as well as possessing anti-inflammatory effects. Finally, 54 marine compounds were reported to act on a variety of molecular targets and thus may potentially contribute to several pharmacological classes. Thus, during 2003-2004, research on the pharmacology of marine natural products which involved investigators from Argentina, Australia, Brazil, Belgium, Canada, China, France, Germany, India, Indonesia, Israel, Italy, Japan, Mexico, Morocco, the Netherlands, New Zealand, Norway, Panama, the Philippines, Portugal, Russia, Slovenia, South Korea, Spain, Thailand, Turkey, United Kingdom, and the United States, contributed numerous chemical leads for the continued global search for novel therapeutic agents with broad spectrum activity.

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Author information

Author/s: Mayer, Alejandro M S (AM); Rodríguez, Abimael D (AD); Berlinck, Roberto G S (RG); Hamann, Mark T (MT);

Affiliation: Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA. amayer(-atsign-)midwestern.edu

Grants: 1R01A136596 (Agency:PHS HHS) ; 1R15 ES012654 (Agency:NIEHS NIH HHS) ; R15 ES012654-01 (Agency:NIEHS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP (Comp Biochem Physiol C Toxicol Pharmacol), published in United States. (Language: eng)

Reference: 2007-May; vol 145 (issue 4) : pp 553-81

Dates: Created 2007/05/04; Completed 2007/07/20; Revised 2008/11/20;

PMID: 17392033, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Anthelmintics - pharmacology Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - pharmacology Anticoagulants - pharmacology Antimalarials - pharmacology Antiprotozoal Agents - pharmacology Antitubercular Agents - pharmacology

Antiviral Agents - pharmacology Biological Products - pharmacology Cardiovascular System - drug effects Humans Immune System - drug effects Marine Biology Nervous System - drug effects Platelet Aggregation Inhibitors - pharmacology

Associated Chemicals: Anthelmintics (0) ; Anti-Bacterial Agents (0) ; Anti-Inflammatory Agents (0) ; Anticoagulants (0) ; Antimalarials (0) ; Antiprotozoal Agents (0) ; Antitubercular Agents (0) ; Antiviral Agents (0) ; Biological Products (0) ; Platelet Aggregation Inhibitors (0)

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