Dopamine genes and pathological gambling in discordant sib-pairs.

Full Abstract

Pathological gambling (PG) is an impulse control disorder that has been considered as a behavioral addiction. Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported. In the present study, 140 sib-pairs discordant for the diagnosis of PG (70 males and 70 females on each group) were recruited through the Gambling Outpatient Unit at the Institute of Psychiatry, University of Sao Paulo and were assessed by trained psychiatrists. A family-based association design was chosen to prevent population stratification. All subjects were genotyped for dopamine receptor genes (DRD1 -800 T/C, DRD2 TaqIA RFLP, DRD3 Ser9Gly, DRD4 48bp exon III VNTR, DRD5 (CA) repeat) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Our results suggest the association of PG with DRD1 -800 T/C allele T (P = .03).

Learn Faster Today Improve your study skills

Author information

Author/s: da Silva Lobo, Daniela Sabbatini (DS); Vallada, Homero P (HP); Knight, Joanne (J); Martins, Silvia S (SS); Tavares, Hermano (H); Gentil, Valentim (V); Kennedy, James L (JL);

Affiliation: Laboratory of Medical Investigation (LIM-23)-Psychopharmacology, Department and Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil. Daniela_Lobo(-atsign-)camh.net

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming (J Gambl Stud), published in United States. (Language: eng)

Reference: 2007-Dec; vol 23 (issue 4) : pp 421-33

Dates: Created 2007/10/02; Completed 2007/11/09;

PMID: 17394052, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Brazil - epidemiology
Comorbidity
Dopamine Plasma Membrane Transport Proteins - genetics
Female
Humans
Impulse Control Disorders - epidemiology; genetics
Male
Middle Aged

Polymorphism, Genetic
Receptors, Dopamine - genetics
Receptors, Dopamine D1 - genetics
Receptors, Dopamine D2 - genetics
Receptors, Dopamine D3 - genetics
Receptors, Dopamine D4 - genetics
Receptors, Dopamine D5 - genetics
Siblings
Substance-Related Disorders - epidemiology; genetics

Associated Chemicals: DRD3 protein, human (0) ; DRD4 protein, human (0) ; DRD5 protein, human (0) ; Dopamine Plasma Membrane Transport Proteins (0) ; Receptors, Dopamine (0) ; Receptors, Dopamine D1 (0) ; Receptors, Dopamine D2 (0) ; Receptors, Dopamine D3 (0) ; SLC6A3 protein, human (0) ; Receptors, Dopamine D4 (137750-34-6) ; Receptors, Dopamine D5 (137750-35-7)

These are the highest related articles currently in the database:

See 100+ related articles.