Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke.

Full Abstract

The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual recognition memory and auditory function (auditory brainstem response). The ETS group showed significantly less novelty preference in the visual recognition task whereas no effects on auditory function were detected. These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link.

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Author information

Author/s: Golub, Mari S (MS); Slotkin, Theodore A (TA); Tarantal, Alice F (AF); Pinkerton, Kent E (KE);

Affiliation: Department of Environmental Toxicology, University of California, Davis, CA 95616, USA.

Grants: ES011634 (Agency:NIEHS NIH HHS) ; ES05707 (Agency:NIEHS NIH HHS) ; RR00169 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in Netherlands. (Language: eng)

Reference: 2007-Jun; vol 1151 (issue ) : pp 102-6

Dates: Created 2007/05/14; Completed 2007/07/24; Revised 2007/12/03;

PMID: 17399690, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acoustic Stimulation - methods
Animals
Animals, Newborn
Evoked Potentials, Auditory, Brain Stem - physiology
Female
Macaca mulatta

Male
Pattern Recognition, Visual - physiology
Photic Stimulation - methods
Pregnancy
Prenatal Exposure Delayed Effects
Tobacco Smoke Pollution

Associated Chemicals: Tobacco Smoke Pollution (0)

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