Pre- and postnatal FGF-2 both facilitate recovery and alter cortical morphology following early medial prefrontal cortical injury.

Full Abstract

Rats with either no treatment or administration of exogenous basic fibroblast growth factor (FGF-2) received bilateral medial prefrontal cortical (mPFC) aspiration or sham lesions at postnatal day 3 (P3). FGF-2 was administered either prenatally at embryonic day 15.5 (PreFGF) or, postnatally (PostFGF) for 7 consecutive days beginning 1 day following surgery. As adults, animals were tested behaviorally at spatial navigation (Morris water task), and skilled reaching (Whishaw tray reaching task). Early lesions of the mPFC produced a significant reduction in both brain weight and cortical thickness in adulthood. Behaviorally, mPFC lesions resulted in deficits in the water maze and reaching task. Both pre- and postnatal FGF-2 facilitated recovery in the spatial navigation task. In contrast, FGF-2 was only effective in reducing the deficits in skilled forelimb movements when the FGF was given postnatal (i.e., postsurgery). Prenatal FGF-2 increased brain weight in the lesion animals, whereas postnatal FGF-2 increased cortical thickness in the lesion animals. It thus appears that FGF-2 can facilitate recovery from perinatal cortical injury, whether it is given during the period of neurogeneration (prenatally) or after the injury, although the mechanism of action is likely different for the pre- and postnatal administration.

Learn Faster Today Improve your study skills

Author information

Author/s: Comeau, Wendy L (WL); Hastings, Erica (E); Kolb, Bryan (B);

Affiliation: Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta. T1K 3M4, Canada.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2007-Jun; vol 180 (issue 1) : pp 18-27

Dates: Created 2007/05/07; Completed 2007/06/28;

PMID: 17408762, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Factors
Analysis of Variance
Animals
Animals, Newborn
Brain Injuries - drug therapy; pathology
Female
Fibroblast Growth Factor 2 - administration & dosage; physiology
Maze Learning - physiology
Motor Skills - physiology

Motor Skills - physiology
Organ Size
Prefrontal Cortex - growth & development; injuries; pathology
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Long-Evans
Recovery of Function - physiology
Sex Factors

Associated Chemicals: Fibroblast Growth Factor 2 (103107-01-3)

These are the highest related articles currently in the database:

See 100+ related articles.