Diffusion tensor imaging of normal appearing white matter and its correlation with cognitive functioning in mild cognitive impairment and Alzheimer's disease.

Full Abstract

Diffusion tensor imaging (DTI) was used to examine the microstructural integrity of normal appearing white matter (NAWM) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Significant frontal, temporal, and parietal white matter diffusion tensor changes were demonstrated in MCI and AD compared with normal controls. These changes were correlated with cognitive functioning, and are consistent with a hypothesized loss of axonal processes in affected regions.

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Author information

Author/s: Huang, Juebin (J); Auchus, Alexander P (AP);

Affiliation: Department of Neurology, University of Tennessee Health Science Center, 855 Monroe Ave., Suite 415, Memphis, TN 38163, USA. jhuang8(-atsign-)utmem.edu

Grants: P50AG08012 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2007-Feb; vol 1097 (issue ) : pp 259-64

Dates: Created 2007/04/06; Completed 2007/04/25; Revised 2007/12/03;

PMID: 17413027, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Alzheimer Disease - pathology; psychology
Axons - pathology
Brain - pathology
Cognition Disorders - pathology; psychology
Diffusion Magnetic Resonance Imaging

Female
Humans
Image Processing, Computer-Assisted
Male
Neuropsychological Tests
Psychomotor Performance - physiology

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