Research article summary (published 29 Sep 2006):

Effect of mesenchymal stem cell transplantation on cognitive functions in rats with ischemic stroke.

Full Abstract

The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals.

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Author information

Author/s: Sokolova, I B (IB); Fedotova, O R (OR); Zin'kova, N N (NN); Kruglyakov, P V (PV); Polyntsev, D G (DG);

Affiliation: Trans-Tekhnologiya Company, Russian Academy of Medical Sciences, St. Petersburg.

Journal and publication information

Publication Type: Journal Article

Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med), published in United States. (Language: eng)

Reference: 2006-Oct; vol 142 (issue 4) : pp 511-4

Dates: Created 2007/04/06; Completed 2007/06/13;

PMID: 17415450, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Brain Ischemia - physiopathology; psychology; therapy Cognition - physiology Disease Models, Animal Flow Cytometry Male Maze Learning

Maze Learning Mesenchymal Stem Cell Transplantation Middle Cerebral Artery - surgery Rats Rats, Inbred WKY Reference Values Swimming

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