A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate.

Full Abstract

Numerous lines of evidence have highlighted the involvement of the dopamine system in the pathophysiology of schizophrenia. Association studies of dopaminergic genes such as the dopamine D2 receptor gene (DRD2), however, have produced contradictory results. To test the hypothesis that DRD2 polymorphisms are associated with schizophrenia, we investigated two DRD2-related polymorphisms (TaqI A1/A2 or rs1800497 and -141-C Ins/Del or rs1799732) in a Spanish population isolate from northern Spain consisting of 165 controls and 119 patients with schizophrenia. The TaqI A1 allele was less frequent in schizophrenic patients than in controls (P=0.002). A similar association was found for the TaqI A2/A2 genotype (P=0.0003). No association was found for the DRD2 -141-C Ins/Del polymorphism. The strong association between a potentially functional polymorphism, downstream of the DRD2 gene and schizophrenia, suggests that the direct or indirect functional effects of this polymorphism, acting on either the ANKK1 or DRD2 genes, may play a role in the pathophysiology of schizophrenia.

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Author information

Author/s: Parsons, Michael J (MJ); Mata, Ignacio (I); Beperet, Maria (M); Iribarren-Iriso, Fernando (F); Arroyo, Barbara (B); Sainz, Ricardo (R); Arranz, Maria J (MJ); Kerwin, Robert (R);

Affiliation: Clinical Neuropharmacology, Institute of Psychiatry, KCL, London, UK. m.parsons(-atsign-)iop.kcl.ac.uk

Journal and publication information

Publication Type: Journal Article

Journal: Psychiatric genetics (Psychiatr Genet), published in England. (Language: eng)

Reference: 2007-Jun; vol 17 (issue 3) : pp 159-63

Dates: Created 2007/04/09; Completed 2007/08/06;

PMID: 17417059, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

DNA - blood; genetics; isolation & purification
European Continental Ancestry Group - genetics
Humans
Polymorphism, Genetic
Receptors, Dopamine D2 - genetics

Receptors, Dopamine D2 - genetics
Rural Population
Schizophrenia - genetics
Sequence Deletion
Spain

Associated Chemicals: Receptors, Dopamine D2 (0) ; DNA (9007-49-2)

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