Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia.

Full Abstract

The glutamatergic system has been implicated in the pathogenesis and prefrontal cortex dysfunctions in schizophrenia. The Src-family tyrosine kinase Fyn plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate, in prefrontal cortex. We estimated an association between three polymorphisms of Fyn gene and performance on the Wisconsin Card Sorting Test, measuring prefrontal cortex functions, in 188 schizophrenic patients. Patients with T/T genotype of IVS10+T/C polymorphism and T/T genotype of Ex12+894T/G polymorphism made significantly less perseverative errors in the Wisconsin Card Sorting Test compared with patients with remaining genotypes, and obtained numerically better results in other Wisconsin Card Sorting Test domains. No significant differences in Wisconsin Card Sorting Test performance were found as to -93 A/G polymorphism. The main finding of the study is showing a relationship between polymorphisms of the Fyn gene, related to the function of glutamatergic system, and a performance on neuropsychological test of prefrontal cortex activity in schizophrenic patients.

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Author information

Author/s: Rybakowski, Janusz K (JK); Borkowska, Alina (A); Skibinska, Maria (M); Hauser, Joanna (J);

Affiliation: Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland. rybakows(-atsign-)wlkp.top.pl

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Psychiatric genetics (Psychiatr Genet), published in England. (Language: eng)

Reference: 2007-Jun; vol 17 (issue 3) : pp 201-4

Dates: Created 2007/04/09; Completed 2007/08/06;

PMID: 17417065, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Female
Genotype
Humans
Male
Middle Aged

Middle Aged
Neuropsychological Tests
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-fyn - genetics
Schizophrenia - enzymology; genetics
Schizophrenic Psychology

Associated Chemicals: Proto-Oncogene Proteins c-fyn (EC 2.7.1.112)

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