Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures.

Full Abstract

Movement-related processing results in the modulation of neuronal synchronization over several electroencephalography (EEG) frequency ranges, including alpha- (8-12 Hz) and beta-band (14-30 Hz). Whether modulation patterns differ across sites within the motor system remains unclear, but could denote how information is conveyed across the cortico-basal network. We therefore compared the event-related synchronization/desynchronization (ERS/ERD) in recordings from the scalp, basal ganglia and thalamic structures during a motor task. Simultaneous depth and scalp EEG were recorded in 13 patients, undergoing deep brain stimulation of the thalamic ventral intermediate nucleus (VIM) or the subthalamic nucleus (STN). They performed a choice-reaction task with pre-cued Go-signals, instructive for either left- or right-sided button presses. In the beta-band, pre-cues and Go-signals were followed by ERD starting well before and peaking at task execution, uniformly in all cortical and subcortical recordings. In contrast, a comparable alpha-band ERD was only seen at the scalp, whereas mirror-like ERS were observed in the motor-inhibitory STN. In VIM, which receives strong somatosensory afferences, a major alpha-ERD upon the Go-signal did not start until the motor response. These dissociations of task-related Alpha- and Beta-band dynamics tag a functional diversity in cortico-basal networks, which are simultaneously active in motor processing. Whereas the uniform downregulation of Beta-activity points to an anti-kinetic operation mode throughout the motor system, site-dependent courses of Alpha-synchronization rather reflect the coordination of activity levels in functionally divergent motor structures during the preparation and execution of movements.

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Author information

Author/s: Klostermann, Fabian (F); Nikulin, Vadim V (VV); Kühn, Andrea Annette (AA); Marzinzik, Frank (F); Wahl, Michael (M); Pogosyan, Alek (A); Kupsch, Andreas (A); Schneider, Gerd-Helge (GH); Brown, Peter (P); Curio, Gabriel (G);

Affiliation: Department of Neurology, CBF/CVK, Charité-University Medicine Berlin, Berlin, Germany. fabian.klostermann(-atsign-)charite.de

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: The European journal of neuroscience (Eur J Neurosci), published in France. (Language: eng)

Reference: 2007-Mar; vol 25 (issue 5) : pp 1604-15

Dates: Created 2007/04/11; Completed 2007/06/25;

PMID: 17425586, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Female
Humans
Male
Middle Aged
Motor Cortex - physiopathology
Movement Disorders - physiopathology; surgery
Nonlinear Dynamics
Psychomotor Performance - physiology; radiation effects
Reaction Time - physiology; radiation effects

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