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| Research article summary (published 6 Apr 2007): |
Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine.
Full Abstract
The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functionally resembles the well-characterized prokaryotic class IIb KRS, including the propensity to aminoacylate tRNA(Lys) with suboptimal identity elements, as well as non-cognate tRNAs. Transient expression of AtKRS in carrot cells promotes aminoacylation of such tRNAs in vivo and translational recoding of lysine at nonsense codons. Stable expression of AtKRS in Zea mays causes translational recoding of lysine into zeins, significantly enriching the lysine content of grain.
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Author information
Author/s: Wu, Xing Rong (XR); Kenzior, Alexander (A); Willmot, David (D); Scanlon, Sarah (S); Chen, Zhihong (Z); Topin, Andrey (A); He, Shao Hua (SH); Acevedo, Ashley (A); Folk, William R (WR);
Affiliation: Department of Biochemistry, 117 Schweitzer Hall, University of Missouri-Columbia, Columbia, MO 65211, USA.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal: The Plant journal : for cell and molecular biology (Plant J), published in England. (Language: eng)
Reference: 2007-May; vol 50 (issue 4) : pp 627-36
Dates: Created 2007/05/15; Completed 2007/06/25;
PMID: 17425721, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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