Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder.

Full Abstract

ADHD is generally deemed to be a highly heritable disorder with mean heritability of 0.75. The enzyme monoamine oxidase (MAO), which has both A and B types, has long been considered a candidate pathological substrate for ADHD, and more recently, the genes for both MAO enzymes have been examined as mediators of the illness. Previous studies indicated that 30-50% of children with ADHD will experience symptoms that persist into adolescence and will have more significant impairment in social and neuropsychological functioning compared to those whose symptoms have remitted. Genes may also influence these characteristics of the disorder, and in this context MAO genes may also be candidates for moderating the presentation of ADHD. The current study examined the association between adolescent outcome of ADHD and MAO gene polymorphisms, including the 941T > G polymorphism in exon 8 (rs1799835) and 1460C > T polymorphism in exon 14 (rs1137070) of the MAOA gene, and the A > G polymorphism in intron13 (rs1799836), C > T polymorphism in the 3'UTR (rs1040399), and 2327T > C polymorphism in exon15 of the MAOB gene. Significant associations were observed between the MAOA gene polymorphisms and ADHD remission. Due to the small sample size and the possibility of phenotypic and etiologic heterogeneity of ADHD outcomes across ethnic or geographic groups, these results must be replicated before they can be generalized to other populations.(c) 2007 Wiley-Liss, Inc.

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Author information

Author/s: Li, Jun (J); Kang, Chuanyuan (C); Zhang, Haobo (H); Wang, Yufeng (Y); Zhou, Rulun (R); Wang, Bing (B); Guan, Lili (L); Yang, Li (L); Faraone, Stephen V (SV);

Affiliation: Institute of Mental Health, Peking University (Peking University sixth hospital), China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), published in United States. (Language: eng)

Reference: 2007-Jun; vol 144B (issue 4) : pp 430-3

Dates: Created 2007/05/30; Completed 2007/08/14; Revised 2008/05/21;

PMID: 17427196, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Alleles
Attention Deficit Disorder with Hyperactivity - enzymology; genetics
Child
Gene Frequency

Associated Chemicals: Monoamine Oxidase (EC 1.4.3.4)

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