Research article summary (published 27 Feb 2007):

[Experimental study of Qishen Yiqi Dropping Pills on liver fibrosis in rats]

Full Abstract

OBJECTIVE: To investigate the anti-fibrotic effects of Qishen Yiqi Dropping Pills (QYDP) in rats with liver fibrosis (LF). METHODS: The LF model was induced by intraperitoneal injection with dimethylnitrosamine (DMN). Sixty Wistar rats were randomly divided into the normal group, the model group A, the QYDP intervened group , the model group B , and the QYDP treated group B. The degree of LF was evaluated according to 6-phase grading method. The expressions of collagen type I and III and tissue inhibitor of metalloproteinase-1 (TIMP-1) in liver tissues were determined by immunohistochemistry and the levels of collagen type I and III and TIMP-1 mRNA determined by semi-quantitive RT-PCR. RESULTS: Compared with the model group A and B, the degree of LF, the positive expressions of TIMP-1 mRNA and the content of collagen type I and III in liver tissue in the QYDP intervened and treated groups were significantly lower. CONCLUSION: QYDP could reduce the pathological changes and degree of LF in rats, which may be partially through inhibiting the expressions of collagen type I and III and TIMP-1.

Author information

Author/s: Zhu, Yue-ke (YK); Duan, Zhong-ping (ZP); Wang, Bao-en (BE);

Affiliation: Artificial Liver Center, Beijing You'an Hospital, Capital University of Medical Sciences. zhuyk126(-atsign-)126.com

Journal and publication information

Publication Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban (Zhongguo Zhong Xi Yi Jie He Za Zhi), published in China. (Language: chi)

Reference: 2007-Mar; vol 27 (issue 3) : pp 223-6

Dates: Created 2007/04/16; Completed 2008/05/09;

PMID: 17432682, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Collagen Type I - biosynthesis; genetics Collagen Type III - biosynthesis; genetics Drugs, Chinese Herbal - therapeutic use Immunohistochemistry Liver Cirrhosis, Experimental - drug therapy Male

Phytotherapy RNA, Messenger - biosynthesis; genetics Random Allocation Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Tissue Inhibitor of Metalloproteinase-1 - biosynthesis; genetics

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Drugs, Chinese Herbal (0) ; RNA, Messenger (0) ; Tissue Inhibitor of Metalloproteinase-1 (0) ; qishen yiqi (0)

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