Research article summary (published 22 Mar 2007):

Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats.

Full Abstract

We investigated the effect of imipramine on extracellular serotonin (5-HT) and noradrenaline concentrations in the medial prefrontal cortex of rats treated with adrenocorticotropic hormone (ACTH) for 14 days using in vivo microdialysis. Chronic ACTH treatment did not affect basal extracellular 5-HT and noradrenaline concentrations compared with chronic saline treatment. Acute imipramine treatment plus chronic ACTH treatment significantly increased extracellular 5-HT concentrations, compared with imipramine treatment alone. 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a 5-HT1A receptors full agonist, caused a significant decrease in extracellular 5-HT concentrations. However, its inhibitory effect was attenuated by the treatment with ACTH for 14 days. These findings suggest that chronic treatment with ACTH enhances the increasing effect release of 5-HT by imipramine through the desensitization of somatodendritic 5-HT1A autoreceptors.

Author information

Author/s: Kitamura, Yoshihisa (Y); Akiyama, Kozue (K); Hashimoto, Shinji (S); Kitagawa, Kouhei (K); Kawasaki, Hiromu (H); Shibata, Kazuhiko (K); Shinomiya, Kazuaki (K); Suemaru, Katsuya (K); Araki, Hiroaki (H); Sendo, Toshiaki (T); Gomita, Yutaka (Y);

Affiliation: Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan. ykita(-atsign-)pheasant.pharm.okayama-u.ac.jp

Journal and publication information

Publication Type: Journal Article

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2007-Jul; vol 566 (issue 1-3) : pp 113-6

Dates: Created 2007/05/28; Completed 2007/09/19;

PMID: 17459373, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Adrenergic Uptake Inhibitors - pharmacology Adrenocorticotropic Hormone - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Corticosterone - blood Imipramine - pharmacology Male

Male Norepinephrine - metabolism Prefrontal Cortex - drug effects; metabolism Rats Rats, Wistar Receptor, Serotonin, 5-HT1A - agonists Serotonin - metabolism Serotonin Agonists - pharmacology

Associated Chemicals: Adrenergic Uptake Inhibitors (0) ; Antidepressive Agents, Tricyclic (0) ; Serotonin Agonists (0) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Corticosterone (50-22-6) ; Imipramine (50-49-7) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4) ; Adrenocorticotropic Hormone (9002-60-2)

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