Research article summary (published 22 Mar 2007):

Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals.

Full Abstract

Diabetes is often accompanied by lipid abnormalities, which contribute significantly to cardiovascular morbidity and mortality in diabetic patients. Previously, we have demonstrated potent hypoglycemic activity of lyophilized aqueous extract of Murraya koenigii leaves in normal and alloxan induced diabetic rabbits for short duration of 6 h. In this study, we examined the effect of 1 month oral administration of Murraya koenigii aqueous leaves extract in normal and STZ induced severe diabetic rats, at the dose of 300 mg/kg bw, on various biochemical parameters, viz., fasting blood glucose (FBG), total cholesterol (TC), HDL-cholesterol (HDL), triglyceride (TG), alkaline phosphatase (ALKP), serum glutamate oxaloacetate and pyruvate transaminases (SGOT and SGPT) and serum creatinine. In case of diabetic animals fasting blood glucose (FBG) levels of treated animals reduced by 48.2% after 30 days treatment with the aqueous leaves extract. A fall of 19.2 and 30.8% in TC and 22.97 and 37.1% in TG levels were also observed in the case of treated normal as well as diabetic rats, respectively. Feeding the extract increased the HDL-cholesterol level by 16 and 29.4% in normal and diabetic rats, respectively, as compared with their initial values. In the normal rats after 1 month of oral administration of the extract SGOT and SGPT levels were decreased by 21.7 and 25.0%. Serum alkaline phosphatase values of the treated normal animals were also reduced by 33% while negligible change was observed in the normal control animals. In the case of diabetic rats, SGOT and SGPT levels were reduced by 36.7 and 32.2%, respectively, whereas ALKP levels decreased by 39.7% after 1 month oral administration of the extract. The serum creatinine levels decrease in normal as well as in the diabetic animals by 17.75 and 18.2%, respectively, as compared to initial values. In the diabetic control animals the urinary sugar remains at +4 level but there was a decrease of 75% in urine sugar in the case of treated diabetic rats. This indicates that the aqueous extract of Murraya koenigii has favorable effect in bringing down the severity of diabetes.

Author information

Author/s: Kesari, Achyut Narayan (AN); Kesari, Shweta (S); Singh, Santosh Kumar (SK); Gupta, Rajesh Kumar (RK); Watal, Geeta (G);

Affiliation: Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India. achyut_narayan(-atsign-)rediffmail.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)

Reference: 2007-Jun; vol 112 (issue 2) : pp 305-11

Dates: Created 2007/05/22; Completed 2007/08/07;

PMID: 17467937, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Alanine Transaminase - blood Alkaline Phosphatase - blood Animals Antilipemic Agents - pharmacology Aspartate Aminotransferases - blood Blood Glucose - metabolism Body Weight - drug effects Cholesterol, LDL - blood Cholesterol, VLDL - blood Creatinine - blood

Diabetes Mellitus, Experimental - blood; drug therapy; urine Female Glycosuria - urine Hypoglycemic Agents - pharmacology Lipids - blood Male Murraya - chemistry Plant Extracts - pharmacology; therapeutic use Rats Triglycerides - blood

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antilipemic Agents (0) ; Blood Glucose (0) ; Cholesterol, LDL (0) ; Cholesterol, VLDL (0) ; Hypoglycemic Agents (0) ; Lipids (0) ; Plant Extracts (0) ; Triglycerides (0) ; Creatinine (60-27-5) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1)

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