Research article summary (published 5 May 2007):

Chemical constituents of cape aloe and their synergistic growth-inhibiting effect on Ehrlich ascites tumor cells.

Full Abstract

The constituents of cape aloe were investigated after a preliminary screening of the growth-inhibiting effect on Ehrlich ascites tumor cells (EATC) of several extracts of this plant. Ten compounds were isolated from the dichloromethane (CH(2)Cl(2)) extract that showed the strongest activity, and their structures were elucidated as aloe-emodin (1), p-hydroxybenzaldehyde (2), p-hydroxyacetophenone (3), pyrocatechol (4), 10-oxooctadecanoic acid (5), 10-hydroxyoctadecanoic acid (6), methyl 10-hydroxyoctadecanoate (7), 7-hydroxy-2,5-dimethylchromone (8), furoaloesone (9), and 2-acetonyl-8-(2-furoylmethyl)-7-hydroxy-5-methylchromone (10) based on MS and various NMR spectroscopic techniques. Compounds 2-7 were isolated for the first time from cape aloe. Compounds 4-7 and 10 showed a significant growth-inhibiting effect, and compound 1 exhibited a remarkable synergistic effect on compounds 8-10, which was not observed with the treatment by each compound alone on EATC. These results suggest that the strong growth-inhibiting effect of the CH(2)Cl(2) extract was dependent not on one compound alone, but on the synergistic effect from the combination of compound 1 and the other compounds.

Author information

Author/s: Kametani, Saeda (S); Kojima-Yuasa, Akiko (A); Kikuzaki, Hiroe (H); Kennedy, David Opare (DO); Honzawa, Mayumi (M); Matsui-Yuasa, Isao (I);

Affiliation: Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem), published in Japan. (Language: eng)

Reference: 2007-May; vol 71 (issue 5) : pp 1220-9

Dates: Created 2007/05/23; Completed 2007/07/05; Revised 2007/11/15;

PMID: 17485848, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetophenones - chemistry; pharmacology Aloe - chemistry Animals Anthraquinones Antineoplastic Agents - chemistry; pharmacology Benzaldehydes - chemistry; pharmacology Carcinoma, Ehrlich Tumor - drug therapy; metabolism; pathology Catechols - chemistry; pharmacology Cell Survival - drug effects Cells, Cultured Chromones - chemistry; pharmacology

Chromones - chemistry; pharmacology Drug Synergism Emodin - chemistry; pharmacology Mass Spectrometry Methylene Chloride - chemistry Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phytotherapy Plant Extracts - pharmacology; therapeutic use Powders - chemistry Time Factors

Associated Chemicals: Acetophenones (0) ; Anthraquinones (0) ; Antineoplastic Agents (0) ; Benzaldehydes (0) ; Catechols (0) ; Chromones (0) ; Plant Extracts (0) ; Powders (0) ; aloe emodin (0) ; catechol (120-80-9) ; 4-hydroxybenzaldehyde (123-08-0) ; Emodin (518-82-1) ; Methylene Chloride (75-09-2) ; 4-hydroxyacetophenone (99-93-4)

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