Genome sequence of Aedes aegypti, a major arbovirus vector.

Full Abstract

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.

Author information

Author/s: Nene, Vishvanath (V); Wortman, Jennifer R (JR); Lawson, Daniel (D); Haas, Brian (B); Kodira, Chinnappa (C); Tu, Zhijian Jake (ZJ); Loftus, Brendan (B); Xi, Zhiyong (Z); Megy, Karyn (K); Grabherr, Manfred (M); Ren, Quinghu (Q); Zdobnov, Evgeny M (EM); Lobo, Neil F (NF); Campbell, Kathryn S (KS); Brown, Susan E (SE); Bonaldo, Maria F (MF); Zhu, Jingsong (J); Sinkins, Steven P (SP); Hogenkamp, David G (DG); Amedeo, Paolo (P); Arensburger, Peter (P); Atkinson, Peter W (PW); Bidwell, Shelby (S); Biedler, Jim (J); Birney, Ewan (E); Bruggner, Robert V (RV); Costas, Javier (J); Coy, Monique R (MR); Crabtree, Jonathan (J); Crawford, Matt (M); Debruyn, Becky (B); Decaprio, David (D); Eiglmeier, Karin (K); Eisenstadt, Eric (E); El-Dorry, Hamza (H); Gelbart, William M (WM); Gomes, Suely L (SL); Hammond, Martin (M); Hannick, Linda I (LI); Hogan, James R (JR); Holmes, Michael H (MH); Jaffe, David (D); Johnston, J Spencer (JS); Kennedy, Ryan C (RC); Koo, Hean (H); Kravitz, Saul (S); Kriventseva, Evgenia V (EV); Kulp, David (D); Labutti, Kurt (K); Lee, Eduardo (E); Li, Song (S); Lovin, Diane D (DD); Mao, Chunhong (C); Mauceli, Evan (E); Menck, Carlos F M (CF); Miller, Jason R (JR); Montgomery, Philip (P); Mori, Akio (A); Nascimento, Ana L (AL); Naveira, Horacio F (HF); Nusbaum, Chad (C); O'leary, Sinéad (S); Orvis, Joshua (J); Pertea, Mihaela (M); Quesneville, Hadi (H); Reidenbach, Kyanne R (KR); Rogers, Yu-Hui (YH); Roth, Charles W (CW); Schneider, Jennifer R (JR); Schatz, Michael (M); Shumway, Martin (M); Stanke, Mario (M); Stinson, Eric O (EO); Tubio, Jose M C (JM); Vanzee, Janice P (JP); Verjovski-Almeida, Sergio (S); Werner, Doreen (D); White, Owen (O); Wyder, Stefan (S); Zeng, Qiandong (Q); Zhao, Qi (Q); Zhao, Yongmei (Y); Hill, Catherine A (CA); Raikhel, Alexander S (AS); Soares, Marcelo B (MB); Knudson, Dennis L (DL); Lee, Norman H (NH); Galagan, James (J); Salzberg, Steven L (SL); Paulsen, Ian T (IT); Dimopoulos, George (G); Collins, Frank H (FH); Birren, Bruce (B); Fraser-Liggett, Claire M (CM); Severson, David W (DW);

Affiliation: Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. nene(-atsign-)tigr.org

Grants: 5 R01 AI61576-2 (Agency:NIAID NIH HHS) ; R01 AI059492 (Agency:NIAID NIH HHS) ; R01 LM006845-08 (Agency:NLM NIH HHS) ; R37 AI024716 (Agency:NIAID NIH HHS) ; UO1 AI50936 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2007-Jun; vol 316 (issue 5832) : pp 1718-23

Dates: Created 2007/06/25; Completed 2007/07/27; Revised 2008/04/28;

PMID: 17510324, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Science. 2007 Jun 22;316(5832):1703-4. (PMID: 17588917)

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