A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides.

Full Abstract

A new lupene triterpenetriol was isolated from the acetone extract of the aerial parts of Salvia sclareoides and characterised as (1beta,3beta)-lup-20(29)-ene-1,3,30-triol (1). In addition, nepetidin (2), nepeticin (3), lupendiol (4), (1beta,11alpha)-dihydroxy-lup-20(29)-en-3-one (5), ursolic acid (6), sumaresinolic acid (7) and hederagenin (8), were identified in this Salvia sp. To the best of our knowledge, the compounds 2 and 7 are new constituents in Salvia spp. The acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (AChE) and butyrilcholinesterase (BChE), enzymes which play a role in the Alzheimer disease. All extracts inhibited acetylcholinesterase activity at 10 microg/ml, a remarkable activity since the standard drug rivastigmine does not inhibit acetylcholinesterase at the same concentration. Regarding the butyrilcholinesterase, the acetone extract at 1000 microg/ml was able to inhibit completely the enzyme activity and the butanol and ethanol extracts, at this concentration, produced a potent inhibition of BchE.

Author information

Author/s: Rauter, Amélia P (AP); Branco, Isabel (I); Lopes, Rui G (RG); Justino, Jorge (J); Silva, Filipa V M (FV); Noronha, João P (JP); Cabrita, Eurico J (EJ); Brouard, Ignacio (I); Bermejo, Jaime (J);

Affiliation: Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal. aprauter(-atsign-)fc.ul.pt

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Fitoterapia (Fitoterapia), published in Netherlands. (Language: eng)

Reference: 2007-Dec; vol 78 (issue 7-8) : pp 474-81

Dates: Created 2007/10/30; Completed 2008/03/06;

PMID: 17570616, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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