Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.

Full Abstract

The cytokines interleukin-1 (IL-1alpha and IL-1beta) and the tumor necrosis factor-alpha (TNF-alpha) both play a major role in the initiation and regulation of inflammation and immunity responses. Polymorphisms within the gene sequences of these cytokines IL-1 and TNF-alpha have been proposed to play an important role in the pathogenesis of certain diseases. Affecting nearly every organ, various diseases, including some cancers, are described to be associated with an increased level of IL-1 and TNF-alpha proteins, for example, solid tumors, hematologic malignancies, malignant histiocytosis, autoimmune disorders, Alzheimer's disease, Parkinson's disease, sepsis, and rheumatoid arthritis. Regarding genetic backgrounds and pathways, numerous canine diseases show close similarities to their human counterparts. As a genetic model, the dog could be used to unravel the genetic mechanisms, for example, in particular the predispositions, the development, and progression of cancer and metabolic diseases. The identity comparison of gene and protein sequences of different species could be used to elucidate the structure and function of the genes and proteins by identifying the evolutionary conserved regions and domains. Herein we analyzed in detail the mRNA and protein structures and identities of the present known mammalian (human, canine, murine, rat, ovine, equine, feline, porcine, and bovine) TNF-alpha, IL-1alpha, and IL-1beta mRNAs and proteins. Additionally, based on the canine genome sequence, we derived in silico the complete mRNA structures of the IL-1alpha and IL-1beta mRNAs.

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Author information

Author/s: Soller, Jan T (JT); Murua-Escobar, Hugo (H); Willenbrock, Saskia (S); Janssen, Miriam (M); Eberle, Nina (N); Bullerdiek, Jörn (J); Nolte, Ingo (I);

Affiliation: Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, 30137 Hanover, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of heredity (J Hered), published in United States. (Language: eng)

Reference: 2007-; vol 98 (issue 5) : pp 485-90

Dates: Created 2007/08/31; Completed 2007/12/12;

PMID: 17573384, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Dogs - genetics
Humans - genetics
Interleukin-1alpha - genetics
Interleukin-1beta - genetics
Mammals - genetics

Mammals - genetics
RNA, Messenger - genetics
Sequence Homology
Species Specificity
Transcription, Genetic
Tumor Necrosis Factor-alpha - genetics

Associated Chemicals: Interleukin-1alpha (0) ; Interleukin-1beta (0) ; RNA, Messenger (0) ; Tumor Necrosis Factor-alpha (0)

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