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| Research article summary (published 4 May 2007): |
The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L.
Full Abstract
Extracts of Aegopodium podagraria L. were screened in vitro for cyclooxygenase-1 (COX-1) inhibitory activity. The isolation of the active compound falcarindiol was achieved by bioassay-guided fractionation. The identification of the active compound was confirmed by (1)H NMR and (13)C NMR. The IC(50)-value of falcarindiol was 0.3 microM in the COX-1 assay. A quantitative determination of the seasonal variation in the content of falcarindiol in different plant parts was carried out by HPLC analysis. The flowers from Aegopodium podagraria collected in June 2006 had the highest concentration of falcarindiol (88 mg/g plant material).
Author information
Author/s: Prior, Rikke M (RM); Lundgaard, Nanna H (NH); Light, Marnie E (ME); Stafford, Gary I (GI); van Staden, Johannes (J); Jäger, Anna K (AK);
Affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)
Reference: 2007-Aug; vol 113 (issue 1) : pp 176-8
Dates: Created 2007/07/25; Completed 2007/11/13;
PMID: 17574359, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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