Research article summary (published 17 Jun 2007):

Cell signaling: moving to a Wnt-Rap.

Full Abstract

Non-canonical, beta-catenin-independent Wnt signaling regulates cell polarization and movements. A recent study reveals that casein kinase Iepsilon mediates an additional novel non-canonical Wnt pathway via the activation of the Rap1 GTPase during vertebrate gastrulation.

Author information

Author/s: Habas, Raymond (R); He, Xi (X);

Affiliation: Research Tower, Room 629, Department of Biochemistry, UMDNJ-Robert Wood Johnson School of Medicine, 675 Hoes Lane, Piscataway, New Jersey 08854, USA. habasra(-atsign-)umdnj.edu

Journal and publication information

Publication Type: Journal Article

Journal: Current biology : CB (Curr Biol), published in England. (Language: eng)

Reference: 2007-Jun; vol 17 (issue 12) : pp R474-7

Dates: Created 2007/06/20; Completed 2007/09/07;

PMID: 17580081, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Casein Kinase Iepsilon - metabolism Gastrula - physiology Gene Expression Regulation, Developmental Signal Transduction Wnt Proteins - genetics; metabolism

Wnt Proteins - genetics; metabolism Xenopus - embryology; genetics; metabolism Xenopus Proteins - genetics; metabolism Zebrafish - embryology; genetics; metabolism Zebrafish Proteins - genetics; metabolism rap1 GTP-Binding Proteins - genetics; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Wnt Proteins (0) ; Xenopus Proteins (0) ; Zebrafish Proteins (0) ; Casein Kinase Iepsilon (EC 2.7.1.37) ; rap1 GTP-Binding Proteins (EC 3.6.5.2)

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