Research article summary (published 31 May 2007):

7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats.

Full Abstract

The role of nitric oxide (NO) on cognitive performance in a modified elevated plus-maze (mEPM) and passive-avoidance (PA) task was investigated by using the NO synthase (NOS) inhibitor 7-nitroindazole (7-NI) and an NO precursor l-arginine. The interaction between the activation of N-methyl-d-aspartate (NMDA) receptors and NO synthesis on memory retention was also studied. 7-NI, l-arginine or MK-801, a non-competitive NMDA receptor antagonist were injected intraperitoneally (i.p) to male Wistar rats 30 min before the first training session of the PA test or 30 min before on the first day testing (acquisition session) of mEPM task. Transfer latency, the time rat took to move from the open arm to the enclosed arm, was used as an index of learning and memory in a mEPM test. The retention session was performed 24 h after the acquisition one. In the PA task, the retention test was carried out 24 h after training and reduction of retention latency was used to evaluate the acquisition of learning and memory. Blood glucose level and locomotor activity of the rats was also evaluated. 7-NI (10, 20, 25, 50 mg/kg) and MK-801 (0.15 mg/kg) significantly prolonged the transfer latency on retention session in a mEPM test and shortened step-through latency in PA test. 7-NI-induced impairment in memory and learning was partly reversed by l-arginine (200 mg/kg), a competitive substrate for NOS. However subeffective doses of 7-NI (5 mg/kg) and MK-801 (0.075 mg/kg) given in combination significantly impaired plus-maze and PA performances in rats. Thus NMDA receptor mediated NO pathways may be implicated in the PA and mEPM behaviours in rats. Since 7-NI does not affect blood pressure and did not alter blood glucose level and locomotor activity in conscious rats, 7-NI-induced impairment of memory is not due to either hypertension, changes in blood glucose level or effects on locomotor activity.

Author information

Author/s: Yildiz Akar, Furuzan (F); Ulak, Guner (G); Tanyeri, Pelin (P); Erden, Faruk (F); Utkan, Tijen (T); Gacar, Nejat (N);

Affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology 41380 Umuttepe Campus Izmit, Kocaeli, Turkey. firuzanyildiz(-atsign-)superonline.com

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in United States. (Language: eng)

Reference: 2007-Oct; vol 87 (issue 4) : pp 434-43

Dates: Created 2007/08/20; Completed 2007/10/17;

PMID: 17602730, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Anxiety - psychology Arginine - pharmacology Avoidance Learning - drug effects Blood Glucose - metabolism Dizocilpine Maleate - pharmacology Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology

Excitatory Amino Acid Antagonists - pharmacology Indazoles - pharmacology Male Memory - drug effects Nitric Oxide Synthase Type I - antagonists & inhibitors Psychomotor Performance - drug effects Rats Rats, Wistar

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Blood Glucose (0) ; Enzyme Inhibitors (0) ; Excitatory Amino Acid Antagonists (0) ; Indazoles (0) ; 7-nitroindazole (2942-42-9) ; Arginine (74-79-3) ; Dizocilpine Maleate (77086-22-7) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)

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