FnTm2, a novel brain-specific transcript, is dynamically expressed in the song learning circuit of the zebra finch.

Full Abstract

Zebra finch males learn their song by imitation, a process influenced by social variables. The neural pathways for acquisition and production of learned song are known, but the cellular and molecular underpinnings are not. Here we describe a novel gene named "FnTm2" ("Phantom 2") that is predicted to encode a small protein (220 aa) with a single fibronectin type III domain and a single transmembrane domain. This gene shows great variability in its expression in song system neurons of the anterior forebrain pathway (AFP), a circuit that influences song discrimination and is necessary for normal song acquisition. AFP nuclei that express FnTm2 include the nucleus HVC (its Area X-projecting neurons), Area X, and LMAN (core and shell). FnTm2 expression does not correlate with singing behavior like the immediate early gene ZENK. It is expressed variably during sleeping hours and is not dependent on an intact song circuit. FnTm2's expression is sensitive to hearing, because in deafened birds its expression is substantially reduced in the core of LMAN. Furthermore, a comparison of FnTm2 expression between mice and zebra finches revealed a conserved pattern of expression in the "limbic system." We suggest that FnTm2 may be sensitive to affective and/or attentional states and thus may provide insights on how social variables influence the production and discrimination of learned vocalizations. (c) 2007 Wiley-Liss, Inc.

Author information

Author/s: Agate, Robert J (RJ); Hertel, Moritz (M); Nottebohm, Fernando (F);

Affiliation: The Rockefeller University, New York, New York 10021, USA. agater(-atsign-)rockefeller.edu

Grants: 5 T32 MH 15125 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: The Journal of comparative neurology (J Comp Neurol), published in United States. (Language: eng)

Reference: 2007-Sep; vol 504 (issue 2) : pp 127-48

Dates: Created 2007/07/19; Completed 2007/11/13; Revised 2007/12/03;

PMID: 17626267, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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