Research article summary (published 30 Jul 2007):

Synthesis of mono-6-deoxy-6-N,N,N',N',N'-pentamethylethylenediammonio-cyclomaltoheptaose, a single-isomer, monosubstituted, permanently dicationic beta-CD and its use for enantiomer separations by CE.

Full Abstract

The dichloride salt of mono-6-deoxy-6-N,N,N',N',N'-pentamethylethylenediammonio-cyclomaltoheptaose (PEMEDA-BCD), the first single-isomer, monosubstituted, permanently dicationic beta-CD has been synthesized, analytically characterized, and used for the capillary electrophoretic separation of the enantiomers of a group of analytes in acidic and basic BGEs. When the concentration of PEMEDA-BCD was changed in the BGEs, the resulting effective mobilities of the analytes and the respective separation selectivities followed the predictions of the ionic strength-corrected charged resolving agent migration model. Good separation selectivities and favorable normalized EOF mobilities allowed for the rapid, efficient separation of the enantiomers of anionic, weak acid and nonionic analytes in the low- and/or high-pH BGEs.

Author information

Author/s: Nzeadibe, Kingsley (K); Vigh, Gyula (G);

Affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77842-3012, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Electrophoresis (Electrophoresis), published in Germany. (Language: eng)

Reference: 2007-Aug; vol 28 (issue 15) : pp 2589-605

Dates: Created 2007/08/01; Completed 2007/11/06;

PMID: 17657759, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cations, Divalent Electrophoresis, Capillary - methods Hydrogen-Ion Concentration

Hydrogen-Ion Concentration Stereoisomerism beta-Cyclodextrins - chemical synthesis; chemistry

Associated Chemicals: Cations, Divalent (0) ; beta-Cyclodextrins (0) ; betadex (7585-39-9)

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