Research article summary (published 30 Jul 2007):

Antioxidant activities and free radical scavenging potential of Bauhinia microstachya (RADDI) MACBR. (Caesalpinaceae) extracts linked to their polyphenol content.

Full Abstract

Aqueous and hydro-ethanolic extracts of Bauhinia microstachya leaves (AEBM and HEBM) were investigated for their phenolic content and phytochemical profile (by spectrophotometry and HPLC), and for their antioxidant activities and free radical scavenging potential in different in vitro systems (TRAP, TEAC, TBARS, nitric oxide, superoxide and hydroxyl radical). HEBM presented a 27.4% higher content of phenolics when compared to AEBM and a distinct phytochemical profile was observed. Our work suggests that both extracts have potent antioxidant activities and that their antioxidant capacity and efficiency vary according to the radical-generating system. In general, HEBM was more effective than AEBM in avoiding ROS-generating damage and in scavenging the various radicals formed. Nevertheless, when results were normalized to total phenolic content, a different profile of antioxidant activities and free radical scavenging potential was observed, particularly against oxidative lipid damage and superoxide radical. B. microstachya extracts may be considered an interesting source of natural antioxidants as well as other phenolic-rich plants.

Author information

Author/s: Silva, Evandro Gomes da (EG); Behr, Guilherme Antonio (GA); Zanotto-Filho, Alfeu (A); Lorenzi, Rodrigo (R); Pasquali, Matheus Augusto de Bittencourt (MA); Ravazolo, Luis Gustavo (LG); Bordignon, Celso Luis (CL); Silva, Francilene Amaral da (FA); Aboy, Ana Lúcia (AL); Bassani, Valquiria Linck (VL); Henriques, Amélia Teresinha (AT); Reginatto, Flávio Henrique (FH); Dal-Pizzol, Felipe (F); Moreira, José Cláudio Fonseca (JC);

Affiliation: Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035-003 Porto Alegre, RS, Brazil. biovando(-atsign-)gmail.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull), published in Japan. (Language: eng)

Reference: 2007-Aug; vol 30 (issue 8) : pp 1488-96

Dates: Created 2007/08/01; Completed 2007/09/21; Revised 2007/11/15;

PMID: 17666809, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antioxidants - metabolism Bauhinia - chemistry Chromans - pharmacology Chromatography, High Pressure Liquid Ethanol Flavonoids - chemistry; pharmacology Free Radical Scavengers - pharmacology Hydroxyl Radical - metabolism Luminescence Nitric Oxide - metabolism

Nitric Oxide - metabolism Phenols - chemistry; pharmacology Plant Extracts - chemistry; pharmacology Plant Leaves - chemistry Solvents Spectrophotometry, Ultraviolet Superoxides - metabolism Thiobarbituric Acid Reactive Substances - metabolism Water Xanthine Oxidase - metabolism

Associated Chemicals: Antioxidants (0) ; Chromans (0) ; Flavonoids (0) ; Free Radical Scavengers (0) ; Phenols (0) ; Plant Extracts (0) ; Solvents (0) ; Thiobarbituric Acid Reactive Substances (0) ; polyphenols (0) ; Nitric Oxide (10102-43-9) ; Superoxides (11062-77-4) ; Hydroxyl Radical (3352-57-6) ; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (56305-04-5) ; Ethanol (64-17-5) ; Water (7732-18-5) ; Xanthine Oxidase (EC 1.17.3.2)

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