Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage.

Full Abstract

OBJECTIVE:
To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage.

DESIGN:
A nested case-control study.

SETTING:
Biospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1beta, IL-4, IL-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF). PATIENT(S):
Cases of miscarriage (n = 439) were matched to controls (n = 373) by gestational age at sample collection. INTERVENTION(S):
None. MAIN OUTCOME MEASURE(S):
Miscarriage. RESULT(S):
Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% CI 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% CI 0.72-1.28), whereas increased risk related to higher TPO remained. CONCLUSION(S):
Circulating levels of TPO may be associated with increased risk of miscarriage.

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Author information

Author/s: Whitcomb, Brian W (BW); Schisterman, Enrique F (EF); Klebanoff, Mark A (MA); Baumgarten, Mona (M); Luo, Xiaoping (X); Chegini, Nasser (N);

Affiliation: Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Insttutes of Health, Bethesda, Maryland 20852, USA.

Grants: Z01 HD008762-05 (Agency:United States NICHD)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Fertility and sterility (Fertil Steril), published in United States. (Language: eng)

Reference: 2008-Jun; vol 89 (issue 6) : pp 1795-802

Dates: Created 2008/06/03; Completed 2008/08/04;

PMID: 17706203, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Abortion, Spontaneous - blood
Adult
Case-Control Studies
Cytokines - blood
Female
Granulocyte Colony-Stimulating Factor - blood
Humans
Interferon Type II - blood

Interleukin 1 Receptor Antagonist Protein - blood
Interleukins - blood
Maternal Age
Pregnancy - physiology
Reference Values
Socioeconomic Factors
Thrombopoietin - blood
Tumor Necrosis Factor-alpha - blood

Associated Chemicals: Cytokines (0) ; IL1RN protein, human (0) ; Interleukin 1 Receptor Antagonist Protein (0) ; Interleukins (0) ; Tumor Necrosis Factor-alpha (0) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Interferon Type II (82115-62-6) ; Thrombopoietin (9014-42-0)

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